منابع مشابه
When is a further clinical trial justified?
High quality randomised trials provide unbiased estimates of the effects of health interventions, but the findings of a single trial are rarely conclusive. Usually data from several similar trials must be pooled together to draw firm conclusions about the effectiveness of an intervention. This article considers how to determine whether data from existing trials are conclusive and, if not, wheth...
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The issue of mandatory cycle helmets is highly contentious. The aim of this paper is not to argue for or against legislation but to suggest criteria on which the debate should focus. This is done by attempting to answer the question: 'What criteria must be met before cycle helmet wearing is enforced?' Consideration is given to principles, precedents and consequences and four criteria are sugges...
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Since the eradication of smallpox in the 197Os, no other disease has been eliminated from the world by vaccination. Advances in mass immunization campaigns using oral vaccine have successfully interrupted the transmission of wild poliomyelitis virus in many countries, however, and have sharply reduced its incidence in many others (1, 2). The benefits of polio immunization appear from some studi...
متن کاملIs prophylactic antibiotic treatment justified in neonates?
Infections are second leading cause of mortality preceded only by cardiovascular diseases.1 Neonates in particular are at a high-risk of developing bloodstream infections because of their immature immune system and mucosal surfaces.2,3 In neonates, sepsis has repeatedly been indicated to be an important cause of mortality, with preterm and very low birth weight (<1500g) infants being at the hig...
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Over years, the number of patients requiring prolonged mechanical ventilation (PMV) in ICU has increased. Trends in the numbers of patients requiring PMV are of interest to health service planners because they consume a disproportionate amount of healthcare resources, and have high illness costs.1 PMV is defined as need of invasive mechanical ventilation for consecutive 21 days for at least 6 h...
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ژورنال
عنوان ژورنال: Journal of the Royal Society of Medicine
سال: 1991
ISSN: 0141-0768,1758-1095
DOI: 10.1177/014107689108400537